Uncontrolled infections including and not limited to active bacterial infection requiring intravenous IV antibiotics at time of initiating study treatment, fungal infection, human immunodeficiency virus infection with cluster of differentiation 4 CD4 counts less than 350 and or AIDS defining opportunistic illnesses known active hepatitis B for example, hepatitis B surface antigen positive, patients with hepatitis C antibody with detectable hepatitis C viral load
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